{"id":26765,"date":"2024-12-20T11:08:32","date_gmt":"2024-12-20T11:08:32","guid":{"rendered":"https:\/\/cit.upc.edu\/?post_type=portfolio&p=26765"},"modified":"2025-01-15T09:30:17","modified_gmt":"2025-01-15T09:30:17","slug":"dynamic-biomaterials-avancats-antibacterians-per-millorar-la-regeneracio-ossia","status":"publish","type":"portfolio","link":"https:\/\/cit.upc.edu\/ca\/portfolio-item\/dynamic-biomaterials-avancats-antibacterians-per-millorar-la-regeneracio-ossia\/","title":{"rendered":"DYNAMIC: Biomaterials avan\u00e7ats antibacterians per millorar la regeneraci\u00f3 \u00f2ssia"},"content":{"rendered":"\n

09\/01\/2025
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El grup de recerca en Biomaterials, Biomec\u00e0nica i Enginyeria de Teixits (BBT) de l\\’Institut de Recerca i Investigaci\u00f3 en Salut (IRIS) de la Universitat Polit\u00e8cnica de Catalunya \u2013 BarcelonaTech (UPC) treballa en DYNAMIC, un projecte que t\u00e9 com a objectiu crear biomaterials multifuncionals sensibles a est\u00edmuls, capa\u00e7os no nom\u00e9s d\u2019afavorir la regeneraci\u00f3 \u00f2ssia, sin\u00f3 tamb\u00e9 de combatre infeccions bacterianes de manera intel\u00b7ligent i controlada.<\/h4>
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DYNAMIC aborda tres objectius principals:



Desenvolupament de mol\u00e8cules intel\u00b7ligents: Disseny de linkers (connectors moleculars) que nom\u00e9s actu\u00efn en pres\u00e8ncia d\u2019una infecci\u00f3 bacteriana, alliberant p\u00e8ptids antibacterians de manera controlada i temporal. Aquestes mol\u00e8cules detectaran senyals espec\u00edfics de l\u2019entorn infecci\u00f3s, com ara determinades enzims o canvis en el pH.

Creaci\u00f3 de biomaterials avan\u00e7ats: Combinaci\u00f3 d\u2019aquestes mol\u00e8cules intel\u00b7ligents (linkers + p\u00e8ptids antibacterians) amb p\u00e8ptids que promoguin l\u2019adhesi\u00f3 cel\u00b7lular o nanopart\u00edcules de polidopamina per produir biomaterials multifuncionals (implants de titani i hidrogels). Aquestes combinacions oferiran propietats especials per ajudar les c\u00e8l\u00b7lules a adherir-se i combatre les bacteris de manera din\u00e0mica.

Estudi avan\u00e7at d\u2019interaccions: \u00das d\u2019aquests materials com a plataformes avan\u00e7ades per estudiar en temps real les interaccions entre c\u00e8l\u00b7lules i bacteris, amb l\u2019objectiu de desenvolupar nous biomaterials que millorin la regeneraci\u00f3 \u00f2ssia en entorns infecciosos complexos.



Per a aix\u00f2, en primer lloc, se sintetitzaran linkers degradables en pres\u00e8ncia de certes condicions, com el pH \u00e0cid propi de les infeccions bacterianes o per l\\’acci\u00f3 de les proteases, i s\u2019hi afegir\u00e0 un p\u00e8ptid antibacteri\u00e0 (el p\u00e8ptid LF1-11). Al mateix temps, aquests linkers es combinaran amb p\u00e8ptids d\\’adhesi\u00f3 cel\u00b7lular en plataformes pept\u00eddiques o amb nanopart\u00edcules de polidopamina per afavorir la fixaci\u00f3 als teixits.

En segon lloc, es funcionalitzaran superf\u00edcies de titani i hidrogels amb els recobriments multifuncionals per obtenir materials din\u00e0mics amb propietats osteointegratives i antibacterianes.

En tercer lloc, s\\’avaluar\u00e0 la seva efectivitat provant aquests materials amb c\u00e8l\u00b7lules mare i diferents tipus de bacteris per analitzar com funcionen en condicions controlades. Finalment, es provaran les millors combinacions en un model de reparaci\u00f3 d\\’os infectat a la t\u00edbia proximal, amb l\\’objectiu d\\’avaluar la capacitat dels biomaterials per induir la formaci\u00f3 d\\’os in vivo sota infecci\u00f3.

DYNAMIC proposa un enfocament innovador i sense precedents per desenvolupar biomaterials multifuncionals que estimulin el creixement ossi i administrin agents antibacterians de manera controlada i temporal en el context d\u2019una infecci\u00f3. Aquesta estrat\u00e8gia proporciona una soluci\u00f3 innovadora per a la regeneraci\u00f3 del teixit ossi i representa un aven\u00e7 substancial en aquest camp.

\u00a0

Pressupost i finan\u00e7ament<\/h4>

El projecte t\u00e9 una durada de 3 anys (setembre de 2024 – agost de 2027) i compta amb un pressupost de 200.000 \u20ac, procedent de fons dels Projectes de Generaci\u00f3 de Coneixement 2023 (PID2023-148538OB-I00) (Ag\u00e8ncia Estatal d\u2019Investigaci\u00f3).
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El grup de recerca en Biomaterials, Biomec\u00e0nica i Enginyeria de Teixits (BBT) de l’Institut de Recerca i Investigaci\u00f3 en Salut (IRIS) de la Universitat Polit\u00e8cnica de Catalunya \u2013 BarcelonaTech (UPC) treballa en DYNAMIC, un projecte que t\u00e9 com a objectiu crear biomaterials multifuncionals sensibles a est\u00edmuls, capa\u00e7os no nom\u00e9s d\u2019afavorir la regeneraci\u00f3 \u00f2ssia, sin\u00f3 tamb\u00e9 de combatre infeccions bacterianes de manera intel\u00b7ligent i controlada.<\/p>\n","protected":false},"author":5,"featured_media":26843,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"portfolio-types":[959,998,408,1055,1086,153],"class_list":["post-26765","portfolio","type-portfolio","status-publish","has-post-thumbnail","hentry","portfolio-types-biomats-ca","portfolio-types-materiales-de-frontera-ca","portfolio-types-salut","portfolio-types-sector-salut","portfolio-types-tecnologias-de-la-quimica-ca","portfolio-types-tecnologias-de-la-salud-ca"],"yoast_head":"\nDYNAMIC: Biomaterials antibacterians per la regeneraci\u00f3 \u00f2ssia - 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