{"id":18505,"date":"2022-08-10T09:19:45","date_gmt":"2022-08-10T09:19:45","guid":{"rendered":"https:\/\/cit.upc.edu\/?p=18505"},"modified":"2023-04-17T10:43:55","modified_gmt":"2023-04-17T10:43:55","slug":"impuls-a-nous-tractaments-del-cancer-basats-en-el-gas-plasma","status":"publish","type":"post","link":"https:\/\/cit.upc.edu\/ca\/impuls-a-nous-tractaments-del-cancer-basats-en-el-gas-plasma\/","title":{"rendered":"Impuls a nous tractaments del c\u00e0ncer basats en el gas plasma"},"content":{"rendered":"\n

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10\/08\/2022
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Explorar les possibilitats dels plasmes de pressi\u00f3 atmosf\u00e8rica per desenvolupar i consolidar noves ter\u00e0pies m\u00e8diques \u00e9s el principal objectiu de la xarxa PlasTHER, una iniciativa finan\u00e7ada per la Uni\u00f3 Europea en el marc de les accions COST. La xarxa, liderada per la UPC, aglutina grups de recerca, comunitat m\u00e8dica, ind\u00fastria i associacions de pacients de 24 pa\u00efsos europeus que treballaran els propers anys per impulsar nous tractaments per al c\u00e0ncer, la regeneraci\u00f3 i reparaci\u00f3 de teixits o les noves infeccions emergents, entre altres.
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Qu\u00e8 \u00e9s la medicina del gas plasma?<\/h4>
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La medicina del gas plasma \u00e9s un camp interdisciplinari sorgit fa dues d\u00e8cades com una \u00e0rea innovadora entre la f\u00edsica, la qu\u00edmica, l\\’enginyeria i les ci\u00e8ncies de la vida. Es tracta d\\’una \u00e0rea emergent que combina la tecnologia del gas plasma amb la medicina cl\u00ednica i la bioenginyeria amb l\\’objectiu d\\’utilitzar plasmes freds a pressi\u00f3 atmosf\u00e8rica per a aplicacions terap\u00e8utiques humanes i veterin\u00e0ries, per a la desinfecci\u00f3 i cicatritzaci\u00f3 de ferides o en les ter\u00e0pies del c\u00e0ncer, entre altres. Una tecnologia potent que implica un gran nombre d\\’esp\u00e8cies reactives (mol\u00e8cules, \u00e0toms, ions, electrons, fotons, radiaci\u00f3 UV i visible), les quals han demostrat afectar les c\u00e8l\u00b7lules mitjan\u00e7ant procediments bioqu\u00edmics complexos. Aquesta tecnologia obre la porta a noves oportunitats de la medicina del gas plasma.\r
Per\u00f2, malgrat els aven\u00e7os cient\u00edfics i tecnol\u00f2gics en l\\’\u00e0mbit m\u00e8dic, avui dia, els tractaments disponibles basats en aquesta tecnologia encara no s\u00f3n del tot efectius per lluitar contra el c\u00e0ncer, aconseguir la regeneraci\u00f3 i reparaci\u00f3 de teixits o combatre els pat\u00f2gens resistents als f\u00e0rmacs, incloses les infeccions de nova aparici\u00f3. Per fer possible que la tecnologia del gas plasma avanci de forma efectiva en aquestes i altres \u00e0rees, no nom\u00e9s \u00e9s necessari identificar els mecanismes implicats en l\\’acci\u00f3 terap\u00e8utica, sin\u00f3 que tamb\u00e9 cal millorar la coordinaci\u00f3 i la cooperaci\u00f3 de la comunitat cient\u00edfica que treballa en aquest camp des de diverses disciplines, aix\u00ed com la relaci\u00f3 amb la ind\u00fastria.\r
Amb l\\’objectiu d\\’impulsar el desenvolupament d\\’un programa de recerca europeu en medicina del gas plasma i de liderar l\\’activitat europea en aquest \u00e0mbit, s\\’ha posat en marxa l\\’Acci\u00f3 COST Therapeutical applications of Cold Plasma (PlasTHER), liderada per la Universitat Polit\u00e8cnica de Catalunya \u00b7 BarcelonaTech (UPC). El projecte est\u00e0 coordinat per Cristina Canal, investigadora del grup de recerca de Biomaterials, Biomec\u00e0nica i Enginyeria de Teixits (BBT), directora del PlasmaMED lab i professora del Departament de Ci\u00e8ncia i Enginyeria de Materials, vinculada a l\\’Escola d\\’Enginyeria de Barcelona Est (EEBE) i al Centre de Recerca en Enginyeria Biom\u00e8dica (CREB).\r
L\\’Acci\u00f3 PlasTHER est\u00e0 finan\u00e7ada per la Uni\u00f3 Europea en el marc de les accions COST i articula una xarxa de m\u00e9s de cent experts en f\u00edsica, qu\u00edmica, biologia, enginyeria i medicina de 24 pa\u00efsos. Una xarxa sin\u00e8rgica de personal investigador, comunitat m\u00e8dica, ind\u00fastria i associacions de pacients, que durant els propers anys explorar\u00e0 les possibilitats dels plasmes a pressi\u00f3 atmosf\u00e8rica en medicina per compartir, desenvolupar i consolidar les ter\u00e0pies que s\u2019estan investigant actualment, i per fomentar el lideratge d\\’Europa en aquest camp.
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Impulsar les aplicacions biom\u00e8diques del gas plasma<\/h4>
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Una de les prioritats de l\\’Acci\u00f3 PlasTHER \u00e9s impulsar la tecnologia del gas plasma i la seva utilitzaci\u00f3 com a ter\u00e0pia estandarditzada en diverses aplicacions biom\u00e8diques de gran import\u00e0ncia per a la societat, aprofitant, per exemple, el seu potencial antimicrobi\u00e0 en el tractament de la pell i en les ter\u00e0pies del c\u00e0ncer.\r
En aquest sentit, la intensificaci\u00f3 de la recerca en els darrers cinc anys en diferents \u00e0mbits de la medicina del gas plasma \u2013en particular en l\\’esterilitzaci\u00f3 i descontaminaci\u00f3, la cicatritzaci\u00f3 de ferides i el tractament del c\u00e0ncer\u2013 requereix urgentment l\\’harmonitzaci\u00f3 de protocols, aix\u00ed com l\\’orientaci\u00f3 del coneixement generat en una direcci\u00f3 comuna per permetre que tots els esfor\u00e7os i la inversi\u00f3 p\u00fablica fets fins ara en ci\u00e8ncia b\u00e0sica i aplicada es tradueixin en beneficis per a la societat i el sistema sanitari.\r
Amb aquesta finalitat, PlasTHER COST es planteja com una xarxa interdisciplin\u00e0ria que posa en com\u00fa els \u00faltims aven\u00e7os en els mecanismes b\u00e0sics d\\’acci\u00f3 dels plasmes i les condicions de funcionament m\u00e9s adequades per aconseguir ter\u00e0pies eficients. D\u2019altra banda, la xarxa treballar\u00e0 en la generaci\u00f3 de protocols harmonitzats dins la comunitat en les diferents \u00e0rees terap\u00e8utiques implicades, aix\u00ed com en la definici\u00f3 d\\’un full de ruta per a cada \u00e0mbit.\r
Per assolir aquests reptes, la xarxa s\u2019organitza a partir de sis grups de treball, centrats en diferents \u00e0rees de desenvolupament de la tecnologia: els mecanismes d\u2019interacci\u00f3 biol\u00f2gics del gas plasma; els efectes antimicrobians del gas plasma; la regeneraci\u00f3 de teixits; la ter\u00e0pia del c\u00e0ncer; les ter\u00e0pies combinades; i la regulaci\u00f3 \u00e8tica, la difusi\u00f3 i la transfer\u00e8ncia de tecnologia.
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