CP4C: New therapies for bone cancer treatment and tissue regeneration

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The technology of the CP4C project, based on hydrogels treated with plasma gas, is being developed by the team of researchers at the PlasmaMedLab and the Biomaterials, Biomechanics and Tissue Engineering Group (BBT) of CREB at the UPC. CP4C is one of the University projects that has obtained a grant from Barcelona Deep Tech Node to accelerate its launch on the market.

Participants in the project are the Plasmas for BioMedical Applications laboratory (PlasmaMED Lab), which is part of CREB’s Plasmas for Biomedical Applications division of the Biomaterials, Biomechanics and Tissue Engineering Group (BBT) at the UPC. The project is based on developing a treatment for osteosarcoma through plasma-treated liquids (PTL). It has been found that PTLs can kill cancer cells due to the reactive oxygen and nitrogen species (RONS) that they contain. Unlike the side effects produced by chemotherapy, at adequate doses, RONS induce the death of tumour cells without damaging healthy tissues. RONS can be generated in liquids and in hydrogels (PTH) that are injected locally into tumours to achieve controlled release. 

Through these hydrogels, in combination with ceramic materials such as calcium phosphates, a composite material is obtained that eliminates cancer cells due to the action of the RONS and promotes bone regeneration.

The solution is therefore a less aggressive, highly efficient innovative therapy to eradicate bone cancer, with the possibility of regenerating the bone tissue that is affected after surgical resection of the tumour. The anti-cancer potential and safety of treatments with PTL/PTH has been demonstrated in vitro and in vivo. Through CP4C, the aim is to advance in the validation of technology in in vitro environments and in relevant in vivo preclinical animal models, following the guidelines of the corresponding regulatory agencies.

Accelerating technological development

Barcelona Deep Tech Node is a partnership to promote technological and innovative projects between Barcelona City Council, through Barcelona Activa, and the University of Barcelona (UB), the Autonomous University of Barcelona (UAB), the Pompeu Fabra University (UPF) and the Open University of Catalonia (UOC), in addition to the UPC. Since the start of the initiative, a hundred projects and spin-offs from universities and research centres have participated in events, investment forums or mentoring sessions. ‘Proof of Concept’ grants of 225,000 euros provide access to funding for selected projects, accelerate their technological development and cut the time it takes for them to reach the market. In addition, these grants will enable crucial actions to be designed for science and technology-based projects, such as undertaking market studies, formalising patents or presenting projects to investment forums, among others.



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