{"id":29926,"date":"2025-11-27T21:00:00","date_gmt":"2025-11-27T21:00:00","guid":{"rendered":"https:\/\/cit.upc.edu\/portfolio-item\/bio-4d-impressio-4d-de-stents-polimerics-biodegradables-amb-memoria-de-forma-per-a-malformacions-congenites-de-l-arteria-aorta\/"},"modified":"2026-05-06T13:15:22","modified_gmt":"2026-05-06T13:15:22","slug":"bio-4d-4d-printing-of-biodegradable-shape-memory-polymeric-stents","status":"publish","type":"portfolio","link":"https:\/\/cit.upc.edu\/en\/portfolio-item\/bio-4d-4d-printing-of-biodegradable-shape-memory-polymeric-stents\/","title":{"rendered":"BIO-4D: 4D Printing of Biodegradable Shape Memory Polymeric Stents\u00a0"},"content":{"rendered":"\n

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27\/11\/2025<\/p>
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The research groups in Biomaterials, Biomechanics and Tissue Engineering (BBT) and the Barcelona Research Center in Multiscale Science and Engineering (CCEM) at the Universitat Polit\u00e8cnica de Catalunya \u2013 BarcelonaTech (UPC) have developed biodegradable shape-memory stents for pediatric patients with aortic coarctation.<\/h4>
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Aortic coarctation, a narrowing of the aorta, accounts for between 4% and 6% of all congenital heart diseases. It is a highly heterogeneous condition that often coexists with other cardiac abnormalities. Some patients may remain asymptomatic for years; however, when the narrowing is severe, hypertension, headaches, chest pain and muscle weakness may appear. If left untreated, the mortality rate reaches 90% by the age of 50, which is why addressing this condition during childhood is essential.<\/span><\/p>

Current clinical treatments are based on two main strategies. The first is open-heart surgery, in which the narrowed aortic segment is removed. The second, less invasive option consists of balloon angioplasty and the implantation of a permanent metallic endovascular stent, initially designed for adults. In pediatrics, these stents are progressively fractured by surgeons as the aorta increases in diameter with the patient\u2019s growth. Although mortality is below 1\u20132%, neither option is free from long-term complications \u201460% of which are cardiovascular in nature\u2014 such as aneurysms, aortic ruptures, dissections, arrhythmias, hypertension or recoarctation. Moreover, reinterventions continue to be frequent during growth and remain a clinical challenge.<\/span><\/p>

To address these limitations, an <\/span>innovative solution has been developed based on smart stents capable of adapting to the natural expansion of the aorta during childhood. The approach focuses on the development of polymeric, resorbable, shape-memory stents (SMP), manufactured using 3D printing and designed for minimally invasive surgery. This device, activated by body temperature, is biodegradable and designed to restore aortic functionality without leaving obstructive residues. If clinicians need to implant a new stent after 3\u20134 years, no remnants of the original device will remain. In addition, 3D printing technologies applied to smart devices \u2014known as 4D printing\u2014 allow precise customisation to meet the specific needs of each patient.<\/span><\/p>

Impact<\/h4>

The main outcome of this project is the protection of intellectual property, through a patent (PCTEP2025070937), for a new family of resorbable stents that reduce complications, minimise reinterventions and maintain long-term aortic patency, while enabling the continuous refinement of their development. Furthermore, a market study has been carried out, highlighting the technology\u2019s potential and reinforcing both its viability and its market transfer potential to other applications, such as peripheral vascular diseases, providing support in areas like the femoral arteries, as well as paediatric pulmonary stenosis.<\/span><\/p>

Partners and Funding<\/h4>

The project had a budget of \u20ac 20,000 funded by the Ag\u00e8ncia de Gesti\u00f3 d\u2019Ajuts Universitaris i de Recerca (AGAUR) of the Government of Catalonia and lasted six months (from February to July 2024).<\/span><\/p>
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